Current Issue : July - September Volume : 2019 Issue Number : 3 Articles : 5 Articles
Background: Diets rich in fruits, vegetables, and medicinal plants possess antioxidants\npotentially capable of mitigating cellular oxidative stress. This study investigated the antioxidant,\nanti-acetylcholinesterase (AChE), and total phenolic and flavonoids contents (TPC/TFC) of dietary\nsources traditionally used for memory enhancing in Niger Delta, Nigeria. Methods: Dacroydes\nedulis methanolic seed extract (DEMSE), Cola lepidota methanolic seed extract (CLMSE), Terminalia\ncatappa methanolic seed extract (TeCMSE), Tricosanthes cucumerina methanolic seed extract (TrCMSE),\nTetrapleura tetraptera methanolic seed extract (TTMSE), and defatted Moringa oleifera methanolic\nseed extract (DMOMSE); Dennettia tripetala methanolic fruit extract (DTMFE), Artocarpus communis\nmethanolic fruit extract (ACMFE), Gnetum africana methanolic leaf extract (GAMLE), Musa paradisiaca\nmethanolic stembark extract (MPMSE), and Mangifera indica methanolic stembark extract (MIMSE)\nwere evaluated for free radical scavenging antioxidant ability using 2,2-Diphenyl-1-picrylhydrazyl\n(DPPH), reducing power capacity (reduction of ferric iron to ferrous iron), AChE inhibitory potential\nby Ellman assay, and then TPC/TFC contents determined by estimating milli-equivalents of\nGallic acid and Quercetin per gram, respectively. Results: The radical scavenging percentages\nwere as follows: MIMSE (58%), MPMSE (50%), TrCMSE (42%), GAMLE (40%), CLMSE (40%),\nDMOMSE (38%), and DEMFE (37%) relative to.......................
Background: A diet rich in fruits and vegetables contributes to lowering the risk of chronic\ndiseases. The fruits of Malus x domestica are a rich dietary source of bioactive compounds, namely\nvitamins and antioxidants, with recognized action on human health protection. Tuscany is known\nfor its rich plant biodiversity, especially represented by ancient varieties of fruit trees. Particularly\nnoteworthy are the many ancient Tuscan varieties of apple trees. Methods: Sugar quantification via\nHPLC and spectrophotometric assays to quantify the antioxidant power and total polyphenol content\nrevealed interesting differences in 17 old varieties of Malus x domestica Borkh. recovered in Siena\n(Tuscany). Results: The quantification of antioxidants, polyphenols, and the main free sugars revealed\nthat their content in the old fruits was often superior to the widespread commercial counterparts\n(â??Red Deliciousâ?? and â??Golden Deliciousâ??). Such differences were, in certain cases, dramatic, with\n8-fold higher values. Differences were also present for sugars and fibers (pectin). Most ancient fruits\ndisplayed low values of glucose and high contents of xylitol and pectin. Conclusions: The results\nreported here suggest the possible use of ancient apple varieties from Siena for nutraceutical purposes\nand draw attention to the valorization of local old varieties....
The aim of the present research was to study the effects of olive leaf addition (0 and 3%) on\nthe major antioxidants and the antioxidant activity of Neb Jmel and Oueslati olive oils. Olives and\nleaves of the two Tunisian varieties were harvested during the 2016/2017 crop season. Both leaves\nand oils were characterised for their concentrations in phenolics, tocopherols and antioxidant power.\nOther parameters such as free acidity, peroxide value, chlorophyll and carotenoid concentrations were\nalso taken into consideration. Compared to Oueslati, the Neb Jmel oil showed a lower free acidity\n(50%) and peroxide value (5.6-fold), and higher chlorophyll (1.6-fold), total phenolics (1.3-fold),\nflavonoid (3-fold) and oleuropein derivative (1.5-fold) concentrations, in addition to an increased\nantioxidant activity (1.6-fold)......................
Vitamin D deficiency is frequent in the general population and both subjects and health\nprofessionals could benefit from a broader range of vitamin D3 formulations. We conducted a\nsingle-dose, open-label, parallel-group, randomized bioequivalence study to compare a single dose\nof a newly developed vitamin D3 100,000 IU in a soft capsule (Group 1) with the reference drug\nvitamin D3 100,000 IU oral solution in ampoule (Group 2) in healthy volunteers over a four-month\nperiod. The primary endpoint was the area under the curve (AUC) of serum 25-hydroxyvitamin-D\n(25(OH)D) concentrations on Day 112. This study was conducted in France from February to June\n2014 in 53 young adults with a mean age of 26.9 years. At baseline, low mean serum 25(OH)D levels\nwere observed in both groups (10.6 ng/mL in Group 1 and 9.0 ng/mL in Group 2). On Day 112,\nthe AUC of serum 25(OH)D concentration was.....................
The application of plant extracts for therapeutic purposes has been used in traditional\nmedicine since the plants are a source of a great variety of chemical compounds that possess\nbiological activity. Actually, the effect of these extracts on diseases such as cancer is being widely\nstudied. Colorectal adenocarcinoma is one of the main causes of cancer related to death and the\nsecond most prevalent carcinoma in Western countries. The aim of this work is to study the possible\neffect of two fenugreek (Trigonella foenum graecum) protein hydrolysates on treatment and\nprogression of colorectal cancer. Fenugreek proteins from seeds were hydrolysed by using two\nenzymes separately, which are named Purafect and Esperase, and were then tested on differentiated\nand undifferentiated human colonic adenocarcinoma Caco2/TC7 cells. Both hydrolysates did not\naffect the growth of differentiated cells, while they caused a decrease in undifferentiated cell\nproliferation by early apoptosis and cell cycle arrest in phase G1. This was triggered by a\nmitochondrial membrane permeabilization, cytochrome C release to cytoplasm, and caspase-3\nactivation. In addition, the hydrolysates of fenugreek proteins displayed antioxidant activity since\nthey reduce the intracellular levels of ROS. These findings suggest that fenugreek protein\nhydrolysates could be used as nutraceutical molecules in colorectal cancer treatment....
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